Two workshops, a European Union (EU)-U.S. Nano Environmental and Health Safety (NanoEHS) workshop and a nano modeling workshop, will be held in advance of the October 2016 OpenTox Euro Conference. The EU-U.S. NanoEHS workshop, “Enabling a Sustainable Harmonized Knowledge Infrastructure Supporting NanoEHS Assessment,” will be held October 24, 2016. The objective of the workshop is to facilitate networking, knowledge sharing, and idea development on the requirements and implementation of a sustainable knowledge infrastructure for nanoEHS assessment and communications. The workshop will also facilitate active discussions and identify potential partners for future EU-U.S. cooperation on the development of knowledge infrastructure in the nanoEHS field. The nano modeling workshop will be held October 25, 2016. The objectives are to: (1) give the opportunity to research groups working on computational nanotoxicology to disseminate their modeling tools based on hands-on examples and exercises; (2) present a collection of modeling tools that can span the entire lifecycle of nanotox research, starting from the design of experiments until use of models for risk assessment in biological and environmental systems; and (3) engage workshop participants in using different modeling tools and motivate them to contribute and share their knowledge. The OpenTox Euro Conference, “Integrating Scientific Evidence Supporting Risk Assessment and Safer Design of Novel Substances,” will be held October 26-28, 2016. The current topics for the Conference include: (1) computational modeling of mechanisms at the nanoscale; (2) translational bioinformatics applied to safety assessment; (3) advances in cheminformatics; (4) interoperability in action; (5) development and application of adverse outcome pathways; (6) open science applications showcase; (7) toxicokinetics and extrapolation; and (8) risk assessment.