The U.S. National Nanotechnology Initiative (NNI) will hold a virtual stakeholder workshop January 11-13, 2021. NNI states that over the past 20 years, it has supported nanotechnology discovery, development, and deployment and has nurtured the strong ecosystem that exists today. Building on this foundation, nanoscience will underpin a wide range of advanced technologies and enable solutions to challenges into the future. As NNI enters its third decade, conversations at the January 2021 workshop will identify effective mechanisms to advance research and development, strategies for communication, and priority topics to shape future directions. The workshop will take place virtually, and registration information will be available soon.